In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene…

It seems decidedly odd that after more than half a century of both research and clinical experience with autism spectrum disorders (ASDs), there continue to be arguments on the nature of autism. "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ["DSM-5"; American Psychiatric Association (APA), 2013] has not…

Data on psychiatric problems in adults with autism are inconsistent, with estimated rates ranging from around 25% to over 75%. We assessed difficulties related to mental health in 58 adults with autism (10 females, 48 males; mean age 44?years) whom we have followed over four decades. All were of average non-verbal intelligence quotient when…

A follow-up study to at least the age of 21 years of 135 individuals with an autism spectrum disorder diagnosed in childhood and an IQ of over 30 was conducted. The study is distinctive in its large size, low attrition rate and use of systematic interviews to obtain clinical information. Questionnaires completed by caregivers asked about the…

Background: Some young children reared in profoundly depriving institutions have been found to show autistic-like patterns, but the developmental significance of these features is unknown. Methods: A randomly selected, age-stratified, sample of 144 children who had experienced an institutional upbringing in Romania and who were adopted by UK…

The author reviews the history of the definition of autism, cites confusion over varying sets of diagnostic criteria, and reviews research on proposed behavioral grouping. (CL)

Research prospects and priorities in autism are discussed with respect to: (1) diagnosis, classification, and epidemiology; (2) clinical research; (3) neuropsychological research; (4) genetics; (5) structural and functional brain imaging; (6) postmortem studies; (7) other biological research; and (8) treatment research. Application of research…

A study of 319 individuals with autism (ages 3-43) and 113 other subjects found that a single set of criteria, as operationalized by individually structured questions in the Autism Diagnostic Interview and Autism Diagnostic Interview-Revised, was effective in differentiating autism from mental disabilities and language impairment. (Author/CR)

The Autism Diagnostic Observational Schedule (ADOS) is a semi-structured observational scale developed to assess social interaction, communication and play in individuals who are suspected to have autism. Since the ADOS is not suitable to be used with severely or profoundly mentally retarded adolescents and adults with very limited language…