As more and more states contemplate the new school year following the Coronavirus lockdown, teachers, supervisors, and administrators have to determine strategies to safely open their schools. It is hoped that the advice will help guide stakeholders in their decision-making process to be better prepared to meet the current pandemic challenges in starting the new school year with health and safety as the priority. This article was written with the full awareness that governmental guidelines vary from state to state and can change between the publication of this article and the opening of your school. Please follow all local, state, and federal guidelines as they become available. This article focuses on two areas: (1) What are the safest strategies for opening up schools, including but not limited to health, safety and security, curriculum and instruction and facilities; and (2) What specific educational strategies can be used to foster effective teaching/learning activities in Science, STEM, and technology education/engineering. It is based on the best available information that addresses the challenges of this unprecedented situation.