Markerspaces and areas to conduct collaborative STEM activities are becoming increasingly popular in schools, libraries, media centers, and community centers. These are numerous examples of rooms that were originally designed as traditional classrooms being converted into markerspaces or collaborative STEM work areas. This also involved the use of not only hazardous materials but also hand and power tools. Similar to a portable classroom being utilized to facilitate STEM classes during a renovation, this article offers some important safety and design features that should be considered prior to converting a classroom to a markerspace or STEM lab.