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Individual Participant Data Meta-Analysis of Intervention Studies with Time-to-Event Outcomes: A Review of the Methodology and an Applied Example
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de Jong, Valentijn M. T.; Moons, Karel G. M.; Riley, Richard D.; Tudur Smith, Catrin; Marson, Anthony G.; Eijkemans, Marinus J. C.; Debray, Thomas P. A. – Research Synthesis Methods, 2020
Many randomized trials evaluate an intervention effect on time-to-event outcomes. Individual participant data (IPD) from such trials can be obtained and combined in a so-called IPD meta-analysis (IPD-MA), to summarize the overall intervention effect. We performed a narrative literature review to provide an overview of methods for conducting an…
Descriptors: Meta Analysis, Intervention, Randomized Controlled Trials, Guidelines
Empirical Comparison of Univariate and Multivariate Meta-Analyses in Cochrane Pregnancy and Childbirth Reviews with Multiple Binary Outcomes
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Price, Malcolm J.; Blake, Helen A.; Kenyon, Sara; White, Ian R.; Jackson, Dan; Kirkham, Jamie J.; Neilson, James P.; Deeks, Jonathan J.; Riley, Richard D. – Research Synthesis Methods, 2019
Background: Multivariate meta-analysis (MVMA) jointly synthesizes effects for multiple correlated outcomes. The MVMA model is potentially more difficult and time-consuming to apply than univariate models, so if its use makes little difference to parameter estimates, it could be argued that it is redundant. Methods: We assessed the applicability…
Descriptors: Comparative Analysis, Medical Research, Correlation, Meta Analysis