There's no silver bullet to information security; universities must continue to keep their antivirus, anti-spyware, firewall, and patch management systems in good working order. These days, the largest target for hackers appears to be university databases. Now, universities are searching for new solutions to safeguard those systems. This article discusses five key security trends that will reshape how universities defend their databases in 2008 and beyond: (1) Encryption; (2) Information Leakage; (3) Wireless; (4) Appliances; and (5) Open Source. Together, these five leading trends provide a comprehensive data security framework for today's universities. However, universities also must leverage best practices and common sense for effective IT security.