This is an update of a 1991 review on tumor suppressor genes written at a time when understanding of how the genes work was limited. A recent major breakthrough in the understanding of the function of tumor suppressor genes is discussed. (LZ)

Discusses one mechanism proposed for the two-step initiation/promotion scenario of the development of cancer called oncogenes and a possible alternate mechanism that may prevent tumors from developing. Uses the example of retinoblastoma to illustrate the mechanisms. States that these mechanisms may not be caused by the activation of oncogenes. (CW)

Reviews major developments in areas that are at the cutting edge of biological research. Areas include: human anti-cancer gene, recombinant DNA techniques for the detection of Huntington disease carriers, and marine biology. (CW)

Discussed are the uses of sea urchins in research and their usefulness and advantages in the classroom investigation of embryology. Ideas for classroom activities and student research are presented. Lists 25 references. (CW)

The Advances in Biological Sciences program at California State University described in this report has provided 160 high school, junior high, and fifth and sixth grade science teachers with lectures, laboratories, lesson planning, and implementation guidance in forefront biology over the past 3 years. Over 200 program lessons have been…