Inquiry-based classroom is widely distributed in the school science based on its useful and effective instruction. Science teachers are key elements allowing students to have scientific inquiry. If teachers understand and imply inquiry-based learning into science classroom, students will learn science as scientific inquiry and understand nature of science. This study aims to explore how nature of science is engaged through inquiry-based classroom in teacher preparation program. Data are collected by qualitative methods; classroom observation, videotape recording, photography, and interview are employed during April-May 2013. Participants are preservice science teachers, Guangxi Normal University, China. The findings showed that inquiry-based classroom is suitable for preservice science teachers. They perceived nature of science at high level and let them to have positive attitude towards science. That is, it helps them to understand nature of science and reach the goal of science education. Then, scientific inquiry and nature of science will be employed to science classroom. [This study has been supported by the Faculty of Education, Mahasarakham University, Thailand.]