This paper provides readers with an overview of the unique issues present in secondary classrooms and their impact on the practice of collaborative teaching between general and special educators. The authors focus on the changes that are occurring in secondary classrooms related to varied structures (such as block scheduling), higher standards, high stakes testing, a more diverse society, and how co-teaching can better address these issues. Readers are provided with practical strategies to enhance the effectiveness of teachers working together as well as tips to avoid the potential pitfalls when teaming at the secondary level. (Contains 1 table.)