Methodological barriers have been highlighted as a primary reason for the limited research with lesbian, gay, and bisexual (LGB) people of color. Thus, strategies for anticipating and addressing potential methodological barriers are needed. To address this need, this article discusses potential challenges associated with conducting research with LGB people of color and describes specific strategies for addressing these challenges. Each step of the research process--from development of research questions to interpretation and dissemination of results--is discussed. This discussion concludes with a summary of recommended strategies for advancing the quality and quantity of future scholarship with LGB people of color.