This multi-level, longitudinal study investigated the ecumenical worldview development of 13,932 students enrolled in one of 126 institutions. Results indicated that the final hierarchical linear model, consisting of institution-and-student-level predictors as well as slopes explaining the relationships among some of these predictors, explained 39.98% of variance in Time 2 ecumenical worldview. Specifically, differences in ecumenical development trajectories for men and women could be partially explained by the average amount of religious struggle reported by students. Implications for college impact researchers and student development scholars are discussed.