On the basis of stress and coping theory, the authors examined coping as a mediator of the relationship between perceptions of racism and racism-related stress with a sample of Asian American college students (N = 336). Results indicated that coping mediated the relationship between racism and racism-related stress differentially by gender. The more that men perceived racism, the more likely they were to use support-seeking coping strategies that were associated with higher levels of racism-related stress. The more that women perceived racism, the more they used active coping strategies that were associated with higher levels of racism-related stress. The findings demonstrate how coping with racism differs for Asian Americans on the basis of gender.