Based on 164 undergraduate business majors, we examined the relationship between satisfaction with major and Holland's vocational interests and with the Big Five and narrow personality traits. Contrary to our hypothesis, enterprising scores were unrelated to major satisfaction. As hypothesized, using ipsative and normative scores, investigative, artistic, and realistic interests were negatively related to major satisfaction. As hypothesized, conscientiousness, emotional stability, and optimism were positively related to major satisfaction, as were extra-version and assertiveness. A stepwise multiple regression analysis indicated that 49% of the variance in major satisfaction could be accounted for by a combination of vocational interest themes and personality traits. Implications were drawn for theory and practice, including support for Holland's continuity principle, adding personality traits to Holland's vocational theory, and using vocational interest and normal personality trait measures in student advising and career counseling. Study limitations and implications for future research were noted. (Contains 2 tables.)