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Adleman, Nancy E.; Kayser, Reilly; Dickstein, Daniel; Blair, R. James R.; Pine, Daniel; Leibenluft, Ellen – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Outcome and family history data differentiate children with severe mood dysregulation (SMD), a syndrome characterized by chronic irritability, from children with "classic" episodic bipolar disorder (BD). Nevertheless, the presence of cognitive inflexibility in SMD and BD highlights the need to delineate neurophysiologic similarities and…
Descriptors: Attention Deficit Hyperactivity Disorder, Psychological Patterns, Neurological Organization, Severe Disabilities
Pine, Daniel S.; Guyer, Amanda E.; Leibenluft, Ellen; Peterson, Bradley S.; Gerber, Andrew – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
The use of functional magnetic resonance imaging in investigating pediatric anxiety disorders is studied. Functional magnetic resonance imaging can be utilized in demonstrating parallels between the neural architecture of difference in anxiety of humans and the neural architecture of attention-orienting behavior in nonhuman primates or rodents.…
Descriptors: Pediatrics, Anxiety Disorders, Diagnostic Tests, Radiology
Mueller, Sven C.; Maheu, Francoise S.; Dozier, Mary; Peloso, Elizabeth; Mandell, Darcy; Leibenluft, Ellen; Pine, Daniel S.; Ernst, Monique – Neuropsychologia, 2010
Early-life stress (ES) has been associated with diverse forms of psychopathology. Some investigators suggest that these associations reflect the effects of stress on the neural circuits that support cognitive control. However, very few prior studies have examined the associations between ES, cognitive control, and underlying neural architecture.…
Descriptors: Psychopathology, Adolescents, Parents, Stress Variables