Due to fragmented and misaligned segments of public education, many students lack access to educational opportunities that will ensure their success in college and career. This problem is one that may only be solved through better alignment and coordination between high school and college, between systems of higher education, and between education and economic development sectors. Intersegmental collaborations are emerging as a key lever for change, and the sustainability of these intersegmental efforts both depend on and offer opportunities to bridge research, policy, and practice in ways that facilitate improved outcomes. This brief summarizes lessons for effective collaboration and highlights opportunities for bridging research, policy, and practice to increase student success in college and career.