Large-scale efforts to address the need for data sharing and communication have surfaced in recent years. While these efforts have expanded data sharing and data use opportunities for educational institutions at all levels, the comprehensive educational and workforce data across California that are necessary to effectively inform efforts aimed at improving educational outcomes are not yet in place. To more directly address these challenges, regional intersegmental partnerships are emerging across the state. In these partnerships, stakeholders from multiple educational, workforce, and community sectors work collaboratively to improve the educational attainment and workforce outcomes of the students they serve. Although partnerships' goals may differ, partnerships often share a common focus on data sharing and data-informed improvement efforts. Through these regional efforts, important lessons have emerged. In this brief, the authors share these lessons and highlight promising practices from intersegmental partnerships across California. Drawing on more than 30 interviews of key leaders from 27 education and community organizations, a survey of higher education administrators, and an extensive document review, they describe the efforts of local leaders to solve regional challenges related to student outcomes and economic demands. They focus specifically on the conditions necessary for data sharing and current practices in data management, analysis and reporting, and use of data to inform improvement efforts. [For the accompanying resource guide, see ED591078.]