Inuit communities in Northern Quebec (Canada) are exposed to environmental contaminants, particularly to mercury, lead and polychlorinated biphenyls (PCBs). Previous studies reported adverse associations between these neurotoxicants and memory performance. Here we aimed to determine the associations of pre- and postnatal exposures to mercury, lead…

Two models of vulnerability to socioenvironmental risk were examined in 337 African American children (M = 7.8 years) recruited to overrepresent prenatal alcohol or cocaine exposure: The cumulative risk model predicted synergistic effects from exposure to multiple risk factors, and the fetal patterning of disease model predicted that prenatal…

Infant symbolic play was examined in relation to prenatal alcohol exposure and socioenvironmental background and to predict which infants met criteria for fetal alcohol syndrome (FAS) at 5 years. A total of 107 Cape-Colored, South African infants born to heavy drinking mothers and abstainers/light drinkers were recruited prenatally. Complexity of…

Tests 242 newborns exposed prenatally to low levels of polychlorinated biphenyls from maternal consumption of contaminated lake fish. The Brazelton Neonate Scale was used to assess behavioral outcomes. Contaminated fish consumption predicted motoric immaturity, poorer labeling of states, a greater amount of startle, and abnormally weak…

In four year olds who had been exposed to polychlorinated biphenyls (PCBs) before birth, prenatal exposure was associated with less efficient visual discrimination processing and more errors in short memory scanning. Postnatal exposure was unrelated to cognitive performance. (GLR)

Through their marine-based diet, the Inuit of Nunavik (Quebec) are exposed to neurotoxic environmental contaminants that impact cognitive development. Mercury levels in Nunavik Inuit mothers and newborns were higher than in U.S. and Canadian populations but lower than in previous Arctic samples. Lead, polychlorinated biphenyls, chorinated…

Examined methodological issues related to the detection and evaluation of behavioral toxicity in infants and children, focusing on the selection of appropriate variables and strategies to control for confounding, sampling strategies and the problem of "overcontrol" for confounding; and the evaluation of dose-response relations and…

In this paper, we respond to the criticisms and concerns raised by D.V. Cicchetti, A.S. Kaufman, & S.S. Sparrow (this issue) in their review of the PCB literature, with particular attention to our own research in Michigan. We agree that multiple comparisons and functional significance are issues that would benefit from more discussion.…