Web-based self-learning (WBSL) provides learners with a powerful means of acquiring knowledge. However, WBSL may disorient learners, especially when their skills are inadequate for regulating their learning. In this paper, a Web 2.0 self-regulated learning (Web2SRL) system based on the theory of self-regulated learning is proposed. Learners use the Web2SRL system to read articles in RSS feeds from blogs of interest. The Web2SRL system provides learners with mechanisms for regulating their learning, including planning, practice, and reflection. The results of pre- and post-tests show that the Web2SRL system supports knowledge acquisition in WBSL contexts, especially for low-achieving learners. The results of a questionnaire indicate that learners perceive the Web2SRL system to be useful in supporting WBSL. The proposed system can thus play an important role in supporting WBSL. (Contains 6 tables and 2 figures.)