Low high school graduation rates and sharply declining employment rates among disadvantaged youth have led to increasing numbers of youth who are disconnected from both school and work. What programs and policies might prevent these disconnections and improve educational and employment outcomes, particularly among young men? We review the evidence base on "youth development" policies for adolescents and young teens; programs seeking to improve educational attainment and employment for "in-school" youth; and programs that try to "reconnect" those who are "out of school" and frequently out of work, including public employment programs. We identify a number of programmatic strategies that are promising or even proven, based on rigorous evaluations, for disadvantaged youth with different circumstances, and conclude that policy efforts need to promote a range of approaches to engage and reconnect youth, along with ongoing evaluation efforts to improve our understanding of what works, including which program components, for whom. (Contains 20 endnotes.)