Charter schooling continues to grow apace. The nation's four-thousand-plus charter schools now enroll more than a million students and are approaching (or have exceeded) traditional district enrollment in communities like Dayton, Ohio; New Orleans, Louisiana; and Washington, D.C. Many of the most successful charter school providers are embarking on ambitious growth plans; most notably, the famed KIPP Academies hope to nearly double the number of their schools in the next five years, from fifty-seven to roughly one hundred. The climate for expansion seems hospitable: President Obama has called for doubling federal support for charter school facilities. But what will it take for charter schooling to succeed at scale? When it comes to talent management, one approach for building scale is to encourage schools to emulate "best practices." The appeal of mitosis-style growth or "best practice" imitation is undeniable, yet the evidence is that large-scale education reform will not be delivered by following such a course. Instead, the authors of this article argue that a more promising course to help successful new ventures grow effectively is to reconsider, and appropriately retool, the factors that fueled early success. (Contains 22 notes.)