This paper examines institutional restructuring in higher education for the 1990s and the 21st century and the leadership required for that restructuring. Following an overview and a discussion of selected pertinent demographic, social, economic, technological, and political variables, the paper focuses on the strategic importance of Mid-America to changes occurring in Eastern and Western Europe and the newly industrialized countries of the Pacific Rim. There follows a discussion of the learning enterprise in the schools and colleges of the United States. This is a prelude to a review of an agenda for the 1990s which recommends: (1) analysis of conditions of society and establishments; (2) transforming trend analyses into action plans; (3) development of leadership and human resources; and (4) emphasizing integrity within the learning enterprise. This agenda could lead, it is argued, to the creation of an infrastructure for developing world class information era learning communities. A description of such institutions covers leadership qualities and role, planning for quality technology, and the relationship of society, work and education. Also included are 43 footnotes and citations of 3 other documents. (Author/JB)