The incorporation of epistemic aspects of science in science education continues to be a challenge for researchers and practitioners. The paper presents an empirical study investigating how epistemic framing of scientific methods can be incorporated in science teaching, learning and summative assessment, and what impact such framing has on student learning outcomes. The study was conducted with 969 secondary students taught by 152 teachers from a national sample in England. Teaching videos and summative assessments were framed by Brandon's Matrix, a theoretical framework derived from the work of a philosopher of science and focusing on the diversity of scientific methods ranging from hypothesis testing to non-manipulative parameter measurement. The findings are discussed, including (a) the students' views on the teaching videos and summative assessments, (b) the impact of the teaching videos on students' understanding of the epistemic aspects of scientific methods and (c) students' performance on summative assessments in the context of science topics covered in high-stakes examinations in England. The findings suggest that the students' understanding of scientific methods significantly improved after watching the videos. Furthermore, the students' performance on the summative assessment items indicated a high level of accuracy in responses.