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Disterhoft, John F.1
Ohno, Masuo1
Silva, Alcino J.1
Tseng, Wilbur1
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Ohno, Masuo; Tseng, Wilbur; Silva, Alcino J.; Disterhoft, John F. – Learning & Memory, 2005
Little is known about signaling mechanisms underlying temporal associative learning. Here, we show that mice with a targeted point mutation that prevents autophosphorylation of [alpha]CaMKII ([alpha]CaMKII[superscript T286A]) learn trace eyeblink conditioning normally. This forms a sharp contrast to the severely impaired spatial learning in the…
Descriptors: Conditioning, Animals, Associative Learning, Eye Movements