We propose that negative clauses are generally interpreted as if the affirmative portion of the clause is under discussion, a likely topic. This predicts a preference for affirmative (topical) antecedents over negative antecedents of a following missing verb phrase (VP). Three experiments tested the predictions of this hypothesis in sentences containing negation in the first clause followed by an ambiguous as-clause as in "Don't cross on red as a stupid person would" and its counterpart with "smart" replacing "stupid." In Experiment 1 sentences containing an undesirable attribute adjective such as "stupid" were rated as more natural, and read faster, than their desirable attribute counterparts ("smart"), with or without a comma preceding as. The second experiment indicated that the interpretation of the missing VP reflected the attribute adjective's desirability, with processing difficulty presumably reflecting reanalysis from the initial affirmative antecedent (cross on red) to include negation when the initial interpretation violated plausibility. A third experiment generalized the effect beyond sentences with an initial contracted "don't."