NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 5 results Save | Export
A Novel Cysteine-Rich Neurotrophic Factor in "Aplysia" Facilitates Growth, MAPK Activation, and Long-Term Synaptic Facilitation
Peer reviewed Peer reviewed
Direct linkDirect link
Pu, Lu; Kopec, Ashley M.; Boyle, Heather D.; Carew, Thomas J. – Learning & Memory, 2014
Neurotrophins are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. Our previous studies examining neurotrophins and memory formation in "Aplysia" showed that a TrkB ligand is required for MAPK…
Descriptors: Brain, Memory, Learning Processes, Neurological Organization
Activity-Dependent Inhibitory Gating in Molecular Signaling Cascades Induces a Novel Form of Intermediate-Term Synaptic Facilitation in "Aplysia Californica"
Peer reviewed Peer reviewed
Direct linkDirect link
Fischbach, Soren; Kopec, Ashley M.; Carew, Thomas J. – Learning & Memory, 2014
Mechanistically distinct forms of long-lasting plasticity and memory can be induced by a variety of different training patterns. Although several studies have identified distinct molecular pathways that are engaged during these different training patterns, relatively little work has explored potential interactions between pathways when they are…
Descriptors: Inhibition, Memory, Neurological Organization, Training Methods
Growth Factor Signaling and Memory Formation: Temporal and Spatial Integration of a Molecular Network
Peer reviewed Peer reviewed
Direct linkDirect link
Kopec, Ashley M.; Carew, Thomas J. – Learning & Memory, 2013
Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g.,…
Descriptors: Brain, Neurological Organization, Adults, Memory
The Tail-Elicited Tail Withdrawal Reflex of "Aplysia" Is Mediated Centrally at Tail Sensory-Motor Synapses and Exhibits Sensitization across Multiple Temporal Domains
Peer reviewed Peer reviewed
Direct linkDirect link
Philips, Gary T.; Sherff, Carolyn M.; Menges, Steven A.; Carew, Thomas J. – Learning & Memory, 2011
The defensive withdrawal reflexes of "Aplysia californica" have provided powerful behavioral systems for studying the cellular and molecular basis of memory formation. Among these reflexes the (T-TWR) has been especially useful. In vitro studies examining the monosynaptic circuit for the T-TWR, the tail sensory-motor (SN-MN) synapses, have…
Descriptors: Memory, Genetics, Animals, Neurological Organization
The Roles of MAPK Cascades in Synaptic Plasticity and Memory in "Aplysia": Facilitatory Effects and Inhibitory Constraints
Peer reviewed Peer reviewed
Direct linkDirect link
Sharma, Shiv K.; Carew, Thomas J. – Learning & Memory, 2004
Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in "Aplysia" is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and…
Descriptors: Memory, Perceptual Motor Learning, Sensory Experience, Sensory Training