The authors explore the hypothesis that career decision-making self-efficacy could be affected by negative career thoughts, Big Five personality factors, and cultural mistrust in a sample of African American and Caucasian college students. Findings demonstrated that negative career thinking, openness, and conscientiousness explained a significant amount of variance in career decision-making self-efficacy in a general sample of college students, but no unique variance was explained by cultural mistrust in a sample of African American college students. (Contains 3 tables.)