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Weaver, Matthew T.; Branch, Marc N. – Journal of the Experimental Analysis of Behavior, 2008
Tolerance to effects of cocaine can be modulated by schedules of reinforcement. With multiple ratio schedules, research has shown an inverse relationship between ratio requirement and amount of tolerance that resulted from daily administration of the drug. In contrast, tolerance to the effects of cocaine on behavior under multiple interval…
Descriptors: Reinforcement, Cocaine, Intervals, Animals