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Treatment Moderators and Predictors of Outcome in the Treatment of Early Age Mania (TEAM) Study
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Vitiello, Benedetto; Riddle, Mark A.; Yenokyan, Gayane; Axelson, David A.; Wagner, Karen D.; Joshi, Paramjit; Walkup, John T.; Luby, Joan; Birmaher, Boris; Ryan, Neal D.; Emslie, Graham; Robb, Adelaide; Tillman, Rebecca – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: Both the diagnosis and treatment of bipolar disorder in youth remain the subject of debate. In the Treatment of Early Age Mania (TEAM) study, risperidone was more effective than lithium or divalproex in children diagnosed with bipolar mania and highly comorbid with attention-deficit/hyperactivity disorder (ADHD). We searched for…
Descriptors: Attention Deficit Hyperactivity Disorder, Obesity, Schizophrenia, Symptoms (Individual Disorders)
Clinical, Demographic, and Familial Correlates of Bipolar Spectrum Disorders among Offspring of Parents with Bipolar Disorder
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Goldstein, Benjamin I.; Shamseddeen, Wael; Axelson, David A.; Kalas, Cathy; Monk, Kelly; Brent, David A.; Kupfer, David J.; Birmaher, Boris – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). Method: Subjects included 388 offspring, ages 7-17 years,…
Descriptors: Mental Disorders, Risk, Children, Adolescents
Substance Use and the Treatment of Resistant Depression in Adolescents
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Goldstein, Benjamin I.; Shamseddeen, Wael; Spirito, Anthony; Emslie, Graham; Clarke, Greg; Wagner, Karen Dineen; Asarnow, Joan Rosenbaum; Vitiello, Benedetto; Ryan, Neal; Birmaher, Boris; Mayes, Taryn; Onorato, Matthew; Zelazny, Jamie; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Despite the known association between substance use disorders and major depressive disorder (MDD) among adolescents, little is known regarding substance use among adolescents with MDD. Method: Youths with MDD who had not improved after an adequate selective serotonin reuptake inhibitor trial (N = 334) were enrolled in the Treatment of…
Descriptors: Sexual Abuse, Schizophrenia, Drug Use, Suicide
First Episode of Depression in Children at Low and High Familial Risk for Depression
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Williamson, Douglas E.; Birmaher, Boris; Axelson, David A.; Ryan, Neal D.; Dahl, Ronald E. – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To examine the development of first-onset major depressive disorder (MDD) in children at high and low familial risk for depression in a prospective study. Method: High-risk children (n = 76) who were free of any lifetime affective disorder and had at least one first-degree and one second-degree relative with a lifetime history of…
Descriptors: Psychiatry, Age, Schizophrenia, Mothers
Child Mania Rating Scale: Development, Reliability, and Validity
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Pavuluri, Mani N.; Henry, David B.; Devineni, Bhargavi; Carbray, Julie A.; Birmaher, Boris – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To develop a reliable and valid parent-report screening instrument for mania, based on DSM-IV symptoms. Method: A 21-item Child Mania Rating Scale-Parent version (CMRS-P) was completed by parents of 150 children (42.3% female) ages 10.3 plus or minus 2.9 years (healthy controls = 50; bipolar disorder = 50;…
Descriptors: Child Behavior, Check Lists, Schizophrenia, Rating Scales