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Barad, Mark; Cain, Christopher K.; Blouin, Ashley M. – Learning & Memory, 2004
Extinction of classically conditioned fear, like its acquisition, is active learning, but little is known about its molecular mechanisms. We recently reported that temporal massing of conditional stimulus (CS) presentations improves extinction memory acquisition, and suggested that temporal spacing was less effective because individual CS…
Descriptors: Active Learning, Animals, Learning Processes, Cues
Ponnusamy, Ravikumar; Nissim, Helen A.; Barad, Mark – Learning & Memory, 2005
Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized…
Descriptors: Memory, Behavior Modification, Fear, Anxiety