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Direct linkBredy, Timothy W.; Barad, Mark – Learning & Memory, 2008
Histone modifications contribute to the epigenetic regulation of gene expression, a process now recognized to be important for the consolidation of long-term memory. Valproic acid (VPA), used for many years as an anticonvulsant and a mood stabilizer, has effects on learning and memory and enhances the extinction of conditioned fear through its…
Descriptors: Behavior Modification, Long Term Memory, Fear, Anxiety
Bredy, Timothy W.; Wu, Hao; Crego, Cortney; Zellhoefer, Jessica; Sun, Yi E.; Barad, Mark – Learning & Memory, 2007
Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting and depends on regulated gene expression. Epigenetic mechanisms make an important contribution to persistent changes in gene expression; therefore,…
Descriptors: Psychotherapy, Behavior Modification, Long Term Memory, Fear
Ponnusamy, Ravikumar; Nissim, Helen A.; Barad, Mark – Learning & Memory, 2005
Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized…
Descriptors: Memory, Behavior Modification, Fear, Anxiety
