Each generation of students inevitably must confront anew the fundamental questions of meaning and value that have vexed human beings down through the ages. As students have struggled with these "Big Questions," individually and collectively, liberal education has traditionally sought to provide them with a variety of cultural and historical perspectives, as well as to foster their analytical ability to confront and explore answers, necessarily provisional and often competing, for themselves. In practice, however, there are significant challenges, from lack of student interest and faculty expertise to the persistence of inadequate professional paradigms and reward structures. In this article, the authors provide responses to the Big Questions that engage today's students, which may concern religion; developing a sense of purpose; or how learning can be linked to what matters to each individual.