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A Placebo-Controlled, Fixed-Dose Study of Aripiprazole in Children and Adolescents with Irritability Associated with Autistic Disorder
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Marcus, Ronald N.; Owen, Randall; Kamen, Lisa; Manos, George; McQuade, Robert D.; Carson, William H.; Aman, Michael G. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: To evaluate the short-term efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Method: Two hundred eighteen children and adolescents (aged 6-17 years) with a diagnosis of autistic disorder, and with behaviors such as tantrums, aggression, self-injurious behavior, or a…
Descriptors: Check Lists, Self Destructive Behavior, Safety, Autism
Trial Design Challenges when Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
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Scahill, Lawrence; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Handen, Benjamin; Johnson, Cynthia; Dziura, James; Butter, Eric; Sukhodolsky, Denis; Swiezy, Naomi; Mulick, James; Stigler, Kimberly; Bearss, Karen; Ritz, Louise; Wagner, Ann; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2009
This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes…
Descriptors: Intervention, Pervasive Developmental Disorders, Parent Education, Drug Therapy
The Repetitive Behavior Scale-Revised: Independent Validation in Individuals with Autism Spectrum Disorders
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Lam, Kristen S. L.; Aman, Michael G. – Journal of Autism and Developmental Disorders, 2007
A key feature of autism is restricted repetitive behavior (RRB). Despite the significance of RRBs, little is known about their phenomenology, assessment, and treatment. The Repetitive Behavior Scale-Revised (RBS-R) is a recently-developed questionnaire that captures the breadth of RRB in autism. To validate the RBS-R in an independent sample, we…
Descriptors: Caregivers, Phenomenology, Interrater Reliability, Factor Analysis
Thioridazine Dose Effects with Reference to Stereotypic Behavior in Mentally Retarded Residents.
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Aman, Michael G.; White, Anthony J. – Journal of Autism and Developmental Disorders, 1988
Evaluation of 11 moderately/profoundly retarded residents receiving long-term thioridazine treatment found that ratings of hyperactivity and self-injury were significantly lower during the higher dose condition, that high-stereotypy subjects responded better to the drug than low-stereotypy subjects, but that no overall drug effects could be…
Descriptors: Behavior Patterns, Drug Therapy, Hyperactivity, Institutionalized Persons
Risperidone and Adaptive Behavior in Children with Autism
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Williams, Susan K.; Scahill, Lawrence; Vitiello, Benedetto; Aman, Michael G.; Arnold, L. Eugene; McDougle, Christopher J.; McCracken, James T.; Tierney, Elaine; Ritz, Louise; Posey, David J.; Swiezy, Naomi B.; Hollway, Jill; Cronin, Pegeen; Ghuman, Jaswinder; Wheeler, Courtney; Cicchetti, Domenic; Sparrow, Sara – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change. Method: Forty-eight children (5 years to 16 years, 5 months) who showed behavioral improvement during acute…
Descriptors: Daily Living Skills, Behavior Problems, Socialization, Autism
Factor Analysis of the Nisonger Child Behavior Rating Form in Children with Autism Spectrum Disorders
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Lecavalier, Luc; Aman, Michael G.; Hammer, David; Stoica, Wendy; Mathews, Gregory L. – Journal of Autism and Developmental Disorders, 2004
The Nisonger Child Behavior Rating Form (NCBRF) is a behavior rating scale designed for children and adolescents with mental retardation. The purpose of this study was to explore the psychometric properties of the NCBRF in a sample of 330 children and adolescents with autism spectrum disorders (ASDs). Parent and teacher ratings were independently…
Descriptors: Factor Analysis, Construct Validity, Child Behavior, Children