This article explains the basic ideas and practical challenges in clinical trials of new medicines to show the practical application of statistics in the real-world. The article explores the key considerations for the objectives and design of clinical trials and how these relate to the statistical investigation process. The article also includes…

In teaching of experiments for medical students, by using the isolation of mononuclear cells and identification of B lymphocytes, an experiment was developed that integrated biochemistry, cytology, and immunology techniques, from which the students performed a series of operations including spleen separation, isolating mononuclear cells, and…

We consider the effect on estimation of simultaneous variable centering and interaction effects in linear regression. We technically define, review, and amplify many of the statistical issues for interaction models with centering in order to create a useful and compact reference for teachers, students, and applied researchers. In addition, we…

The technology surrounding stem cells generates great excitement amongst scientists, media and the community. For science teachers, this means not only embracing and keeping track of the rapid growth and ongoing development in this field but also tackling the ethical and legislative issues surrounding the topic. So what are stem cells, what is all…

In this lesson, a ready-to-teach cooperative reading activity, students learn about the effects of plastics in our environment, specifically that certain petrochemicals act as artificial estrogens and impact hormonal activities. Much of the content in this lesson was synthesized from recent medical research about the impact of xenoestrogens and…

English titles of medical research articles (RAs) are of great importance, the quality of which can, to a certain degree, affect impact factors of the articles, because many readers will make a decision as to whether to read on after reading titles. However, the special genre has not been extensively studied to date. This paper is designed to…

The war on cancer has been waged for nearly 40 years, yet the cancer burden remains high, especially among minority and underserved populations. One strategy to make strides in the war on cancer and its disparate impacts is to increase the diversity of the cancer research workforce. We describe an approach to recruit a diverse population of future…

Discusses the role of dogs in research, considering their use in studies related to: behavior; aging; anesthesia; gastrointestinal surgery; the brain; organ transplants; radiobiology; trauma and shock; arterial diseases; hemophelia; ophthalmology; diabetes; nutrition; cancer; lupus; cyclic neutropenia; thyroiditis; hepatitis; skeletal system,…

Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)

It seems hard to believe that Dolly the cloned sheep was born 10 years ago, kindling furious arguments over the prospects and ethics of cloning a human. Today, the controversy over cloning is entwined, often confused, with concerns over the use of human embryonic stem cells. Most people are unclear what cloning is, and they know even less when it…

In departure from the standard approach of using several problems to cover specific topics in a class, I use a single problem to cover the contents of the entire semester-equivalent biochemistry classes. I have developed a problem-based service-learning (PBSL) problem on HIV/AIDS to cover nucleic acid concepts that are typically taught in the…

Describes the research efforts of scientists involved in discovering chemical transmission of the nerve impulse. The work includes that of J.N. Langley, George Oliver, Edward A. Schafer, Reid Hunt, Henry Dale, Henry Wellcome, Otto Loewi, and others. The discovery and the importance of both acetylcholine and adrenaline are also discussed. (84…

Compares scientific explanations of addiction of the 1920s and 1930s to today's. Details the history of addiction testing and research, the development of criteria for defining addiction, and both physiological and psychological definitions of addiction. Suggests that the changing status of addiction as a disease reflects different meanings…

This booklet provides information for teachers about the value of appropriate animal use in the classroom and some suggestions for assuring the proper care and use of animals in education. Discussion includes: (1) the importance of animals in education; (2) contributions of animals in classroom learning; (3) contributions of animals to science…

Recommends that an ethical approach to animal research must start early, pointing out that teachers have the opportunity and responsibility to represent the research community and to communicate the benefits of animal research to students. A list of alternatives to using animals for medical research/experiments is included. (JN)