This article outlines a thinking framework that any teacher can use to adapt curriculum through a lens of gender diversity. The authors illustrate the adaptation of several sample lessons to achieve three key outcomes: (1) to support and reduce harm to LGBTQ students; (2) to engage all students with inquiry into science in society; and (3) to develop student empathy toward diverse identities and perspectives. Additional resources are included at the end of the article to continue teachers' explorations of creating inclusive classroom culture.