As districts in California have opened for the 2021-22 school year, they have faced the challenging task of keeping students learning safely in person in the midst of the COVID-19 pandemic, which intensified right before schools opened with the spread of the Delta variant of the virus. This brief compiles preliminary information on reopening for the 2021-22 school year in several California districts that are using multilayered mitigation to keep schools open and students, staff, and their families safe, including masking, vaccination, testing, contact tracing, quarantining, handwashing, and ventilation. This brief is part of a Learning Policy Institute initiative to disseminate key public health research and reopening and recovery strategies to educators and policymakers.