The goal of this practice guide is to offer educators specific, evidence-based recommendations that address the challenges of preventing dropout in secondary schools. This guide synthesizes the best publicly available research and shares practices that are supported by evidence. It is intended to be practical and easy for teachers and school leaders to use. The guide includes many examples in each recommendation to demonstrate the concepts discussed. Throughout the guide, examples, definitions, and other concepts supported by evidence are indicated by endnotes within the example title or content. For examples that are supported by studies that meet What Works Clearinghouse design standards, the citation in the endnote is in bold text. Examples without specific citations were developed in conjunction with the expert panel based on their experience, expertise, and knowledge of the related literature. This guide is targeted to school and district administrators, as well as members of student-support teams including school counselors, social workers, psychologists, and teachers. It provides recommendations that can be implemented in conjunction with existing academic curricula and student-support services. This guide contains appendices.