This guide addresses common issues in on-line learning to help the learner to determine how best to prepare in advance, in order to have the most successful experience possible. It is divided into specific sections, each designed to introduce an important part of on-line learning. These include: (1) Access to Technology; (2) Technology Skills; (3) Communication On-line; (4) Course Structure; (5) Learning Style; and (6) Ensuring Your Success. Each section begins with a short overview that introduces an important consideration for e-learning, then provides a set of guiding questions and information, and examples of how these can apply in actual on-line courses. The section concludes with Questions to Ask - a checklist for course preparation and participation.