Enzymes are nature's catalysts, mediating chemical processes in living systems. The study of enzyme function and mechanism includes defining the maximum catalytic rate and affinity for substrate/s (among other factors), referred to as enzyme kinetics. Enzyme kinetics is a staple of biochemistry curricula and other disciplines, from molecular and…

Experimental designs in the social sciences have received increasing attention due to their power to produce causal inferences. Nevertheless, experimental research faces limitations, including limited external validity and unrealistic treatments. We propose combining qualitative fieldwork and experimental design iteratively--moving back-and-forth…

This article seeks to provide researchers and practitioners in laboratory education, particularly those involved in the curriculum design and implementation of teaching laboratories at university level, with a conceptual framework and a working model for an integrated assessment of learning domains, by attending to a more holistic approach to…

This volume provides alternatives for tackling existing empirical, methodological, and analytical challenges. It does so by providing a broad overview of less established, as well as emerging methods, which are of great relevance for current research on professional learning and development. As such, it offers a comprehensive collection of…

An introductory guide to deducing the mechanism of chemical reactions is presented. Following a typical workflow for probing reaction mechanism, the guide introduces a wide range of kinetic and mechanistic tools. In addition to serving as a broad introduction to mechanistic analysis for students and researchers, the guide has also been used by…

An opportunistic experiment is a type of randomized controlled trial that studies the effects of a planned intervention or policy change with minimal added disruption and cost. This guide defines opportunistic experiments and provides examples, discusses issues to consider when identifying potential opportunistic experiments, and outlines the…

As evidence-based reform becomes increasingly important in educational policy, it is becoming essential to understand how research design might contribute to reported effect sizes in experiments evaluating educational programs. The purpose of this study was to examine how methodological features such as types of publication, sample sizes, and…

Both true experiments and regression discontinuity (RD) designs produce unbiased estimates of effects. However, true experiments are, of course, often criticized on equity grounds, whereas RD designs entail sacrifices in terms of statistical precision. In this article, a hybrid of true experiments and RD designs is considered. This hybrid entails…

The problem of obtaining the apparent equation of motion and shape of a moving body from its arbitrary given equation of motion in special relativity is considered. Also the inverse problem of obtaining the body's equation of motion from a known equation of motion of its image is discussed. Some examples of this problem solution are considered. As…

This article explores the practical relevance of pragmatism as a research paradigm through the example of a piece of pragmatic research that not only used both quantitative and qualitative research methods but also exploited the inherent duality of the data analyzed. Thus, the article aims to make the case that pragmatism as a research paradigm…

This article presents a cohesive, empirically grounded categorization system differentiating the types of generalizations students constructed when reasoning mathematically. The generalization taxonomy developed out of an empirical study conducted during a 3-week teaching experiment and a series of individual interviews. Qualitative analysis of…

To investigate the generalizability of the results of single-case experimental studies, evaluating the effect of one or more treatments, in applied research various simultaneous and sequential replication strategies are used. We discuss one approach for aggregating the results for single-cases: the use of hierarchical linear models. This approach…

The purpose of this paper is to offer insights from scholarly literature, related theory, and practical activities that can inform leaders' efforts to allocate resources and create incentives that will result in powerful, equitable learning for all. This document: (1) sketches the context for work and research related to resource allocation…

The scientificalization of educational research methods was always the most predominant in the two tides of educational experiment in China in the twentieth century, the result of which was unexpectedly dissatisfactory, because researchers misunderstood the connotation of scientificalization in such a degree that resulted in the worship for…

In recent years, national policy experts have questioned the overall quality of educational research, and they have suggested that researchers strengthen their scientific methods by maximizing the use of experimental designs. To promote more rigorous methodology, we discuss several new and often-overlooked opportunities for incorporating…