Our system of research self-regulation, designed to provide internal checks and balances for those who participate in research involving human subjects, is under considerable stress. Much of this crisis has been caused by what we call mission creep, in which the workload of IRBs has expanded beyond their ability to handle effectively. Mission…

Reviews much of what is known about microtubules, which are biopolymers consisting predominantly of subunits of the globular protein, tubulin. Describes the functions of microtubules, their structure and assembly, microtube associated proteins, and microtubule-disrupting agents. (TW)

Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)

The advantages and justifications for using small animals in human-oriented research are reviewed. Some of the pitfalls of extrapolating animal-derived data to humans are discussed. Several specific problems with animal experimentation are highlighted. (CW)

Presented is a review of important science news stories of 1989 as reported in the pages of "Science News." Topics include anthropology, astronomy, behavior, biology, biomedicine, chemistry, environment, food science, math and computers, paleobiology, physics, science and society, space sciences, and technology. (CW)

Existing federal government policies and systems to protect against scientific misconduct in government-supported research projects are described, and additional considerations not covered in federal policy are enumerated. Misconduct inquiries and review procedures are outlined. Applicant and institutional responsibility and the role of prevention…

Describes a study which demonstrates that unintended logical connections within scientific literature, which potentially reveal new knowledge, are unmarked by reference citations or other bibliographic clues. Citation analysis of two separate literatures in biomedicine that have a logical link is used to support this hypothesis. (Author/CLB)

An examination of the changes over a ten-year period (from 1972 to 1982) in the number, distribution, and characteristics of Ph.D. faculty of clinical departments of medical schools is provided in this report. Trends in the training and research involvements of this group are stated with special emphasis on an analysis of the factors associated…

The purpose of this guide, developed by the Association of American Medical Colleges group on Graduate Research, Education, and Training (GREAT), is to outline a model process by which graduate programs can measure program success and that can be adapted to particular circumstances and priorities. The first sections of the guide examine the…

Designed to provide assistance in the assessment of the need for biomedical and behavioral research personnel, this report presents research findings related to specific medical careers. The review includes an examination of the system under which biomedical and behavioral scientists are trained for research careers and the United States…

Provides a summary of some of the recent activities of the National Institutes of Health (NIH) from the perspective of the current director. Emphasizes making NIH better known to the American people and presenting the attractions of the many roles in health-related research to young people formulating career plans. (TW)

Science is many things to many people: a way of thinking and an activity of individuals in the laboratory; a highly structured institution that recruits, instructs, and regulates its members; and a sensitive, interactive, and integrated segment of modern culture and society. This book presents an introduction to these aspects of science from the…