Discusses the use of the mixture of a carboxylic acid and sodium borohydride as a reagent. The chemical mechanism of the mixture is described using structural formulas. Lists 15 references. (YP)

Outlines the chemistry of the rapid synthesis of relatively large DNA fragments (100-200 monomers each) with yields exceeding 99 percent per coupling. DNA synthesis methodologies are outlined and a polymer-supported synthesis of DNA using deoxynucleoside phosphoramidites is described with structural formulas. (YP)

This article presents a queuing model simulation of scientific productivity utilizing critical path analysis. Creativity is found to have a large positive effect, a negative effect, or no effect on productivity, depending on the stage of the problem-solving process to which it is applied and the nature of the bottlenecks inherent to the specific…

Tested Richard Duschl's triadic model of the growth of scientific knowledge against research practices of 10 accomplished life scientists. Reports that the scientists were willing to change their aims, methods, or theories and were both realists and relativists depending on the scientific discourse about the phenomena in question. Discusses…

Analysis of reliability among peer reviews of 422 unsolicited articles for the "Journal of Clinical Anesthesia" found that most articles' reviews were consistent or near consistent. However, articles reviewed by two of the editorial board members were much less likely to be accepted than those read by two nonmembers. (Author/MSE)

A discussion of resource allocation for scientific research identifies the ethical principles underlying the present debate and begins to construct a framework for evaluating various resource allocation proposals. The intent is to promote greater consideration of the link between ethics and science resource allocations. (Author/MSE)

Discussed is the way in which a limited number of astronomy research initiatives were chosen and prioritized based on a consensus of members from the Astronomy and Astrophysics Survey Committee. A list of recommended equipment initiatives and estimated costs is provided. (KR)

A survey of 334 biochemists identified 5 patterns of attitudes and beliefs about taking action for scientific misconduct: (1) reputational harm, (2) sanction criteria, (3) whistleblower stigmatization, (4) professional etiquette, and (5) ideological desensitization. Influences of intraprofessional status, departmental cohesion, institutional…

This article explores some of the intellectual bases of the apparent cultural divide between the fields of mathematics and mathematics education research. The chasm is in part attributable to epistemologies or theoretical "paradigms", fashionable in education, that dismiss or deny the integrity of fundamental aspects of mathematical and scientific…

Research is so inextricably embedded within the teaching in the bioscience disciplines that many of us do not question that there is linkage between teaching and research--we simply know that it is true as part of our discipline culture. We, as bioscientists, have written this essay for the bioscience academic community. We start from the point of…

The norms of science define appropriate and inappropriate scholarly or research role performance. The four norms described in this study are (1) universalism: research is assessed on its merit, not particularistic criteria; (2) commonality: research must be made public and shared with the research community; (3) disinterestedness: research is…

The islands of western Lake Erie are rock-bound isles that abound in rocky outcrops and quarries. The rocks of these islands are of two distinct types, Silurian dolomites and Devonian limestones. The dolomites, exposed in the Bass Islands and Sister Islands are virtually devoid of fossils. Conversely, the limestones of Johnson Island, Marblehead,…

Presents current findings and theories on the causes of Down Syndrome. Reviews research which focused on chromosome 21 and the pathologies associated with it. (ML)

Discusses whether machines can think in the same sense that humans think. Provides four conclusions based on axioms of differences between computer programs and human minds. Compares claims of strong and weak artificial intelligence. (YP)

Discusses how handedness at one level may give rise to handedness at another. Presents examples from plants and animals, molecules, atoms, to elementary particles. Examines the chiral symmetry in life and when it starts. (YP)