This article discusses how methodological practices can shape and limit how mixed methods is practiced and makes visible the current methodological assumptions embedded in mixed methods practice that can shut down a range of social inquiry. The article argues that there is a "methodological orthodoxy" in how mixed methods is practiced that currently favors quantitative methodologies, with a mixed methods praxis that positions qualitative methods second and quantitative methods as primary with an overall mixed methods design that is in the service of testing out quantitatively generated theories about the social world. This article upends the current methodological focus on positivism by centering qualitative approaches to mixed methods practice. A qualitative approach seeks to empower individuals' stories with the goal of understanding how they how make meaning within their social world. Through intensive case studies this article demonstrates the synergy of combining methods in the service of qualitatively driven approaches. (Contains 1 table, 7 figures, and 2 notes.)