In 2007, Sanofi Pasteur asked RAND Health, a division of the RAND Corporation, to study the current climate for adolescent immunization in the United States, to recommend broad strategies for immunizing low-income adolescents (through age 18), and to identify promising "on the ground" practices consistent with the proposed strategic framework. To complete the assessment, RAND Health conducted a review of the relevant published and unpublished literature and held a series of key informant interviews. This documented briefing presents the results of their assessment. Some recommendations--such as creating concrete, actionable, and active messaging for adolescents and their parents and fostering school accountability for administering vaccines--can be accomplished within the existing legal framework. Others--such as making parental consent time-enduring and administering consent through a Web portal--have tremendous potential to improve coverage rates among adolescents and children but require modernization of current consent laws. The intended audience includes public health officials, school administrators, and health care providers. [This publication was sponsored by Sanofi Pasteur.]