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Hyperserotoninemia and Antiserotonin Antibodies in Autism and Other Disorders.
Peer reviewed Peer reviewed
Yuwiler, Arthur; And Others – Journal of Autism and Developmental Disorders, 1992
This study examined the linkage between elevated blood serotonin in autism and the presence of circulating autoantibodies against the serotonin 5HT receptor. Results showed elevated blood serotonin was not closely related to inhibition of serotonin binding by antibody-rich blood fractions. Data were insufficient to determine whether people with…
Descriptors: Autism, Medical Research, Physiology
Construction of a Lower Body Negative Pressure Chamber
Peer reviewed Peer reviewed
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Esch, Ben T. A; Scott, Jessica M.; Warburton, Darren E. R. – Advances in Physiology Education, 2007
Lower body negative pressure (LBNP) is an established and important technique used to physiologically stress the human body, particularly the cardiovascular system. LBNP is most often used to simulate gravitational stress, but it has also been used to simulate hemorrhage, alter preload, and manipulate baroreceptors. During experimentation, the…
Descriptors: Research Tools, Metabolism, Human Body, Medical Services
Macrocytosis in Down Syndrome.
Wachtel, Tom J.; Pueschel, Siegfried M. – American Journal on Mental Retardation, 1991
The study, with 61 Down Syndrome (trisomy 21) adult subjects, found that macrocytosis in the absence of anemia was virtually universal and erythrocyte survival half-time was shorter than normal. Findings suggest that erythrocytes have a younger mean age in persons with Down Syndrome, possibly indicating an accelerated aging process of red blood…
Descriptors: Adults, Aging (Individuals), Blood Circulation, Downs Syndrome
Health Benefits of Animal Research: The Dog as a Research Subject.
Gay, William I. – Physiologist, 1984
Discusses the role of dogs in research, considering their use in studies related to: behavior; aging; anesthesia; gastrointestinal surgery; the brain; organ transplants; radiobiology; trauma and shock; arterial diseases; hemophelia; ophthalmology; diabetes; nutrition; cancer; lupus; cyclic neutropenia; thyroiditis; hepatitis; skeletal system,…
Descriptors: College Science, Higher Education, Laboratory Animals, Laboratory Experiments
Health Benefits of Animal Research: The Rat in Biomedical Research.
Gill, Thomas J. – Physiologist, 1985
Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)
Descriptors: Biomedicine, College Science, Higher Education, Laboratory Animals
Dissociation of POMC Peptides after Self-Injury Predicts Responses To Centrally Acting Opiate Blockers.
Sandman, Curt A.; Hetrick, William; Taylor, Derek V.; Chicz-DeMet, Aleksandra – American Journal on Mental Retardation, 1997
This study investigated whether blood plasma levels of pro-opiomelanocortin-derived (POMC) peptides, beta-endorphin-like activity, adrenocorticotrophic hormone, and adrenal cortisol immediately after self injurious behavior (SIB) episodes predicted subsequent response to an opiate blocker in 10 patients with mental retardation. Results suggest…
Descriptors: Behavior Disorders, Biochemistry, Drug Therapy, Medical Research