Background: Mobility limitations increase with age in the general population. Despite a growing population of older adults with intellectual disabilities (ID), mobility is rarely studied in the ID literature. The specific aim of this study was to identify and summarise primary literature investigating mobility limitations in adults with ID.…

ApoE gene polymorphism was examined in 100 adults with Down syndrome with and without dementia (Alzheimer's disease) and 346 control subjects. Additionally, a meta analysis of studies (total N=480 subjects) was performed. Results indicated a similar incidence of the gene across groups but subjects with the allele tended to an earlier onset of…

The effects of using comprehensive geriatric assessment with 24 community-based elderly individuals with mental retardation/developmental disabilities were evaluated. The evaluation found significantly greater numbers of medical and dental diagnoses than were found by the subjects' previous medical evaluations. (Author/DB)

Institutionalized patients with Down syndrome (N=307) were monitored for 5 to 10 years to determine prevalence of Alzheimer-type dementia. Prevalence increased from 11% between ages 40 and 49 to 77% between 60 and 69. All patients 70 and over had dementia. Mean age of onset of dementia was 56 years. Neuropathological findings were consistent with…

The paper describes an "Outreach Study" in a British community which identified 46 adults with mental handicap over 50 years of age who were not in contact with specialist mental handicap service providers. The study's methodology and process are described including a discussion of issues concerned with defining the population.…

Review of the medical charts of 369 adults with mental retardation found increased use of psychoactive medications with subjects 55-years old and older compared to those 20-39 years of age. The increased psychoactive use by elderly adults was associated with independent living and with psychiatric diagnosis. Neuroleptic use was increased for…

Comparison of adults with mental retardation either with or without Down syndrome and under or over 50 years of age found a significantly higher rate of dementia only in Down syndrome subjects over 50. However, the observed incidence based on functional findings was substantially below the presumed 100% prevalence of neuropathological markers of…