Lower body negative pressure (LBNP) is an established and important technique used to physiologically stress the human body, particularly the cardiovascular system. LBNP is most often used to simulate gravitational stress, but it has also been used to simulate hemorrhage, alter preload, and manipulate baroreceptors. During experimentation, the…

Discusses the role of dogs in research, considering their use in studies related to: behavior; aging; anesthesia; gastrointestinal surgery; the brain; organ transplants; radiobiology; trauma and shock; arterial diseases; hemophelia; ophthalmology; diabetes; nutrition; cancer; lupus; cyclic neutropenia; thyroiditis; hepatitis; skeletal system,…

Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)

Discusses issues and the public's concerns related to using laboratory animals for research purposes. Indicates that several perceptions (such as recognizing that the public's attitudes toward respect for animal life are no more irrational than many broader attitudes toward the sacredness of life) characterize the most responsible of recent…

Examines the extent to which issues related to animal experimentation are in conflict and proposes choices that might least comprise them. These issues include animal well-being, human well-being, self-interest of science, scientific validity and responsibility, progress in biomedical and behavioral science, and the future quality of medical care.…

The advantages and justifications for using small animals in human-oriented research are reviewed. Some of the pitfalls of extrapolating animal-derived data to humans are discussed. Several specific problems with animal experimentation are highlighted. (CW)

Three papers and two responses comprise this section comparing the degree to which research is utilized among various professions. Christine H. McGuire, in "Diffusion and Application of New Knowledge in Medicine," states that, because the medical profession must serve people with clearly perceived problems, these practitioners are under…

Investigates use of positron emission tomography (PET) to study in-vivo metabolic processes. Discusses methodology of PET and medical uses. Outlines the production of different radioisotopes used in PET radiotracers. Includes selected bibliography. (ML)

An examination of the changes over a ten-year period (from 1972 to 1982) in the number, distribution, and characteristics of Ph.D. faculty of clinical departments of medical schools is provided in this report. Trends in the training and research involvements of this group are stated with special emphasis on an analysis of the factors associated…

Proposes the triangulation of two qualitative research methods, hermeneutics and grounded theory, to illuminate clinical realities that elude alternative approaches. Discusses how hermeneutics reveals perceptual information about the uniqueness of shared meanings and common practices, and how grounded theory provides a conceptual framework useful…

Designed to provide assistance in the assessment of the need for biomedical and behavioral research personnel, this report presents research findings related to specific medical careers. The review includes an examination of the system under which biomedical and behavioral scientists are trained for research careers and the United States…