The Grignard reagent used in the laboratory synthesis of organic compounds is the product resulting from the reaction of an alkyl or aryl halide with elemental magnesium. Describes the structure, formation, and some reactions of the reagent. (YP)

Reports an experiment for examining protein-ligand binding using the enzyme carbonic anhydrase. Describes the experimental procedures consisting of the syntheses of an azosulfonamide and its complex formation with carbonic anhydrase. (YP)

Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

Chromium(VI) compounds are classified as oxidizers and must be specially packaged and transported for disposal while Cr(III) compounds are considered nonoxidizers. A process which reduces Cr(VI) to Cr(III) by adding sodium metabisulfite followed by neutralization with magnesium hydroxide is explored. (MVL)

Discussed are the potential hazards associated with nitric acid, inorganic and organic nitrate salts, alkyl nitrates, acyl nitrates, aliphatic nitro compounds, aromatic nitro compounds, and nitration reactions. (CW)

Presented are four experiments for use in two wet analysis courses. These include comparisons and enzyme analysis. In each case, the theory behind each experiment is discussed. (CW)

Discusses the mechanism and the change of pH during the reaction. Notes that a dramatic rise in pH occurs when the reaction nears completion. Evaluates theories by other authors. (MVL)

Discusses a symposium which focused on the influence of inorganic chemistry on organic synthesis, the impact of organic chemistry on biochemistry and vice versa, chemical reaction dynamics, and advances in inorganic chemistry. Explains the purpose of the symposium was to illustrate the intellectual dynamism of modern chemistry. (MVL)

Describes a simple redox reaction that occurs between potassium permanganate and oxalic acid that can be used to prepare an interesting disappearing ink for demonstrating kinetics for introductory chemistry. Discusses laboratory procedures and factors that influence disappearance times. (CW)

Describes a laboratory explosion involving 30 percent hydrogen peroxide being heated on a ceramic-top hotplate. Gives three safety suggestions: peroxides should be treated as potential explosion hazards; alternatives to the ceramic-top hotplate for these reactions should be considered; and lab workers should be prepared for the worst possible…

Provided is an empirical method to train students to avoid physical disaster in their work experience. Discussed is a computer program, CHETAH, which can be used in advance of synthesis to classify the possible explosive nature of the products. Plosophoric and auxoplosive weights of many organic groups are listed. (MVL)