Enzymes are nature's catalysts, mediating chemical processes in living systems. The study of enzyme function and mechanism includes defining the maximum catalytic rate and affinity for substrate/s (among other factors), referred to as enzyme kinetics. Enzyme kinetics is a staple of biochemistry curricula and other disciplines, from molecular and…

An introductory guide to deducing the mechanism of chemical reactions is presented. Following a typical workflow for probing reaction mechanism, the guide introduces a wide range of kinetic and mechanistic tools. In addition to serving as a broad introduction to mechanistic analysis for students and researchers, the guide has also been used by…

The Prime Minister's Committee on Natural Science in Education in Great Britain reported in 1918 that "...in many schools more time is spent in laboratory work than the results obtained can justify." Seventy years later this conclusion can often still be drawn. This is particularly a problem in open distance education where laboratory practicals,…

This chapter examines the core analytic elements of randomized experiments for social research. Its goal is to provide a compact discussion for faculty members, graduate students, and applied researchers of the design and analysis of randomized experiments for measuring the impacts of social or educational interventions. Design issues considered…

Describes two new exercises in classical conditioning that use earthworms and houseflies. The animals are available year-round and pose no risk to the students or instructor. The conditioned stimuli are odorants. These elicit a conditioned response of contraction in worms or proboscis extension in flies. (MJP)

Discusses who has the right to determine the use of animals in scientific research which includes medical experimentation and the toxicity testing of compounds, ranging from pesticides to cosmetics. Provides a list of questions for consideration and discussion. (RT)

Describes the necking of polymer sheets that occurs when they are stretched. Discusses the effect and the mechanisms of necking. Lists four references. (YP)

Discusses the role of dogs in research, considering their use in studies related to: behavior; aging; anesthesia; gastrointestinal surgery; the brain; organ transplants; radiobiology; trauma and shock; arterial diseases; hemophelia; ophthalmology; diabetes; nutrition; cancer; lupus; cyclic neutropenia; thyroiditis; hepatitis; skeletal system,…

The Grignard reagent used in the laboratory synthesis of organic compounds is the product resulting from the reaction of an alkyl or aryl halide with elemental magnesium. Describes the structure, formation, and some reactions of the reagent. (YP)

Proposes a simple procedure based on an expansion of the exponential terms of Raoult's law by applying it to the case of the benzene-toluene mixture. The results with experimental values are presented as a table. (YP)

Reports an experiment for examining protein-ligand binding using the enzyme carbonic anhydrase. Describes the experimental procedures consisting of the syntheses of an azosulfonamide and its complex formation with carbonic anhydrase. (YP)

Provides guidelines for translating university science laboratories into middle school science activities. The need for guidelines is based on the authors' discovery that teachers teach what they were taught. Discusses six expected outcomes of middle school science activities: developing science concepts; practicing process skills; quantitative…

Investigates the nature of catastrophic volcanism and the rifting process. Describes two kinds of evidence: quantitative descriptions of rock melting and a wide range of observations. Discusses examples of continent growth in the North Atlantic, India and the Seychelles islands, and the South Atlantic. (YP)

This was an experiment to test the extended discretion laboratory approach versus a guided-inquiry approach for teaching biology in a university setting. Among three criterion variables (examination, reports, and quizzes), only the laboratory report scores showed differences between groups and group-by-instructor interaction. (Author/YP)

Experimental studies conducted since 1980 were reviewed. Each of the 34 studies concerning problem solving is briefly summarized, followed by comments, criticisms, and/or concerns. A summary indicates that experimental research of the 1980s seems to focus on: (1) children's processes, understanding, functioning, difficulties, and representations;…