The treatment of Attention Deficit Hyperactivity Disorder is a matter of ongoing research and debate, with considerable data supporting both psychopharmacological and behavioral approaches. Researchers continue to search for new interventions to be used in conjunction with or in place of the more traditional approaches. These interventions run the…

PRINCE2, which stands for Projects in Controlled Environments, is a project management method covering the organisation, management, and control of projects and is widely used in both government and commercial IT and building projects in the UK. This paper describes the application of PRINCE2 to the management of large clinical trials…

This paper reviews recent findings on the efficacy of psychopharmacological interventions in autism, points out gaps in knowledge of the effects of specific drug classes, and suggests research directions for the future. (Author/DB)

The importance of targeting certain stages in the life cycle of the virus for antiviral therapy is discussed with reference to the Human Immunodeficiency Virus type 1. Research conducted on a core antigen, p24, is described. (MSE)

The molecular properties of Human Immunodeficiency Virus type 1 (HIV-1) reverse transcriptase are summarized and several strategies developed to inhibit its activity are described. (MSE)

A six-point program of diagnostic inquiry and treatment strategy for individuals with behavior disorders in addition to severe or profound mental retardation is presented, which allows alternate etiological hypotheses to be tested in a clinical setting. This format is intended to unify psychopharmacy practice in mental retardation and in general…

This monograph consists of eight papers which refer in one way or another to the pharmacology of cocaine. The papers are: (1) Cocaine 1984: Introduction and Overview" (John Grabowski); (2) "Cocaine: A Growing Public Health Problem" (Edgar H. Adams and Jack Durell); (3) "Neural Mechanisms of the Reinforcing Action of…

The efficacy of the serotonin uptake inhibitor clomipramine in treatment of self-injurious behavior (SIB) was tested using a double-blind, placebo-controlled crossover trial in eight adults with severe/profound mental retardation. Clomipramine treatment was associated with significant improvement in the frequency of SIB, SIB intensity, and…

Describes the chemical analysis and rating system used at "Consumer Reports" in rating antacids. Discusses considerations made concerning dosage and duration of 12 common brands of antacid. (CW)

The purpose of this study was to examine the association between student-life stress and health related quality of life (HRQOL) among Doctor of Pharmacy (Pharm.D.) students. Data were collected for 166 students in the first three years of a Pharm.D. curriculum. Student-Life Stress Inventory scores were significantly negatively correlated to mental…

This collection of papers focuses on definitions, assessment, assessment instruments, and distinctions between attention deficit disorder (ADD) and general learning disabilities or conduct disorders. Part I covers issues of definition and assessment in the following papers: "Methodological Issues in the Classification of ADD" (Jack Fletcher, et…

This book, on the nature and problems of inappropriate drug use by older adults, provides researchers and health practitioners with an up-to-date survey and overview of the literature on drug use, misuse, and abuse among the elderly. The volume provides abstracts of 100 selected scientific articles on the major topic areas in the field. The…

Determining whether stimulant medication improves learning or long-term academic achievement in children with attention deficit-hyperactivity disorder involves consideration of (1) the prescription of higher than optimal doses, and (2) overinclusive treatment involving adverse responders. A study designed to overcome these theoretical deficiencies…

This review is divided into these topics: alkaloids, antibiotics, inorganics, nitrogen and oxygen containing compounds, steroids, sulfur containing compounds, vitamins, techniques, and miscellaneous methods. The review covers from November 1986, to October 1988. (MVL)

Discussed is a designer-drug technology called antisense which blocks messenger RNA's ability to carry information to protein producing sites in the cell. The applications of this drug to AIDS research, cancer therapy, and other diseases are discussed. (KR)