Despite the deleterious mental health and health consequences experiences of perceived discrimination can have on ethnic and racial minorities in the United States, a dearth of qualitative studies exist to develop a better understanding of such experiences. As part of a larger study examining psychosocial stress events, and in an effort to fill this gap, this study sought to explore stressful life experiences of intergroup and within-group perceived discrimination among a heterogeneous sample of U.S.-born and foreign-born Latino youth (n = 170) residing in Los Angeles, California, and Trenton, New Jersey. Focus group methodology was implemented, and data were analyzed using grounded theory and constant comparison method. Findings suggest that Latino youths' experiences of intergroup and within-group discrimination vary by nativity status and region of the United States. Findings may be helpful for researchers, practitioners, and others working with Latino youth. (Contains 1 note.)