Response to intervention (RTI) is a new method of identifying students with learning disabilities. RTI's increasing implementation affects all teachers and students, in both general and special education. The authors provide educators with a practical understanding of what RTI may look like in the classroom and how co-teaching as an instructional service delivery model can make RTI more efficient, effective, and realistic. After introducing the RTI model and its role in supporting a paradigm shift for the identification of students with learning disabilities and the support of at-risk learners, the authors then highlight the important components of collaboration and review the key tenets of effective co-teaching. They provide specific examples to demonstrate how co-teaching and collaboration are critical to the systemic change required for schools interested in supporting an RTI model.