Gateway Public Schools--a middle and high school serving a diverse group of about 800 students in San Francisco--was founded in 1998 by parents of students with learning disabilities seeking a supportive environment for their children. As a public charter organization with a lottery entrance system, Gateway seeks to admit a student body that represents the population of San Francisco's public schools at large, giving priority to local residents and to students eligible for free or reduced-price lunch. Approximately 25% of students enrolled receive special education services, 80% are students of color, and more than 50% are from low-income families. Gateway has a strong reputation for offering excellent supports for students with learning differences and is known for its high graduation and college attendance rates. Gateway's founding ideals--focused on empowering students of all learning styles--have transformed into a set of guiding principles for effectively supporting students of all background that focus on (1) inclusivity and equity; (2) relationships; and (3) continuous improvement. These principles guide a set of structures and practices that are designed to instantiate these philosophies in students' and staff's everyday lived experiences. Each of the structures and practices works in tandem with the others, so there is a mission-driven coherence schoolwide. This case study documents promising school practices that illustrate how the creation of a positive school climate, along with a full and rich curriculum focused on meaningful learning, has led to improved motivation, sense of belonging, and student achievement that outpaces most similarly situated schools in California.